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In vivo effect of CsA or Spongionella compounds on the ear thickness 24 h after DNFB challenge. Mouse ear thickness calculated as the percentage of increment rate (thickness of the challenged ear minus the baseline thickness of the unchallenged ear) of ear swelling of DNFB-sensitized animals and compared to CsA (0.4 mg kg−1), Gracilin H (0.4 mg kg−1) or Gracilin L (0.4 mg kg−1) treated animals. *p < 0.05. Data are mean ± SEM of three mice per group.
