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Gene structures of human UGT1 and UGT2. (A) Human UGT1 gene contains multiple exon 1s and common exons 2–5, and each UGT1 isoform are generated by exon sharing of the gene. Exon 5a produces UGT1A_i1 proteins, while exon 5b produced smaller UGT1A_i2 proteins. (B) UGT2A1 and UGT2A2 are generated by exon sharing of unique exon 1s and common exons 2–6 of the UGT2A gene in the same manner as UGT1A proteins. UGT2A3 and UGT2B family proteins are encoded by each unique gene in a cluster.
