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Proposed model of oligomeric human UGTs. Human UGTs form homo- and hetero-oligomers in ER membrane. As indicated with blue arrows, oligomerization of UGTs might be involved in the transport of substrates and glucuronides across the ER membrane. Protein–protein interactions of human UGT with other microsomal and cytoplasmic proteins such as UGT, CYP, and p53 can make a great impact on glucuronidation, oxidation, apoptosis, carcinogenesis, and oxidative stress.
