Table 2.
Concentration of diclofenac (µg/mL) in vitreous and aqueous humor samples after intravitreal injection of solid lipid nanoparticles containing diclofenac (mean ± SD, n = 3). Right eyes and left eyes were injected with solid lipid nanoparticles containing diclofenac and diclofenac commercial injection, respectively (dose = 0.3 mg).
| Time (hour) | Vitreous samples | Aqueous humor samples | ||
|---|---|---|---|---|
| Right eyes | Left eyes | Right eyes | Left eyes | |
| 1 | 88.94 ± 13.03 | 33.47 ± 22.45 | 10.220 ± 4.943 | 1.564 ± 0.547 |
| 4 | 58.93 ± 17.86 | 3.87 ± 2.11 | 8.661 ± 3.419 | 1.988 ± 1.469 |
| 12 | 1.94 ± 1.31 | 0.30 ± 0.22 | 0.200 ± 0.102 | 0.181 ± 0.109 |
| 24 | 0.24 ± 0.14 | 0.12 ± 0.07 | 0.133 ± 0.041 | 0.113 ± 0.084 |
| 48 | 0.14 ± 0.01 | 0.09 ± 0.06 | 0.076 ± 0.023 | 0.008 ± 0.007 |