. 2016 Oct 19;4:e2582. doi: 10.7717/peerj.2582

Table 2. Results of the estimation of λ₁ from the 32 sets of simulations for which group effect is zero.

					Coverage of 95% confidence intervals						Percentage of estimates < true value
m.v. pattern	Var(ɛ)	a₁	D	Set	Cox.b	Cox.tp	joineR	stjm	JM.pc	JM.sp	Cox.b	Cox.tp	joineR	stjm	JM.pc	JM.sp
Monotone	16	0.02	a	1	94	94	91	94	97	94	24	40	50	52	59	53
			b	2	83	93	92	94	95	95	27	40	52	53	57	52
			c	3	82	88	92	93	69	84	20	24	53	58	90	79
			d	4	92	90	94	95	91	94	44	24	53	57	40	59
		0.1	a	5	88	94	91	96	87	91	33	37	52	56	83	76
			b	6	90	94	93	97	88	92	25	32	50	55	85	80
			c	7	84	85	94	95	NA	96	19	24	47	58	NA	79
			d	8	88	94	91	95	87	91	33	37	52	62	83	76
	4	0.02	a	9	96	95	91	93	96	94	46	52	48	48	56	53
			b	10	92	95	93	93	96	95	43	54	53	53	61	53
			c	11	92	94	96	97	74	83	39	47	49	50	92	82
			d	12	96	95	91	92	96	94	46	52	48	54	56	53
		0.1	a	13	92	95	91	95	89	95	48	46	48	54	74	72
			b	14	92	96	92	95	88	93	48	49	47	54	80	79
			c	15	94	92	94	93	NA	97	35	42	47	60	NA	83
			d	16	92	95	91	94	89	95	48	46	48	58	74	72
Non-monotone	16	0.02	a	17	97	96	93	93	96	90	33	31	60	57	44	58
			b	18	87	94	88	94	94	93	23	40	49	50	51	53
			c	19	85	84	95	95	91	73	21	25	53	53	79	90
			d	20	97	96	93	91	96	90	33	31	60	63	44	58
		0.1	a	21	95	92	94	95	95	91	33	24	45	55	63	81
			b	22	90	88	91	92	95	91	29	21	50	54	62	80
			c	23	84	77	94	94	NA	96	20	12	52	63	NA	89
			d	24	95	92	94	97	95	91	33	24	45	59	63	81
	4	0.02	a	25	94	95	91	95	96	94	58	61	56	58	57	57
			b	26	94	93	92	93	93	93	51	59	52	54	55	55
			c	27	92	93	96	96	93	86	43	37	46	47	70	87
			d	28	94	95	91	93	96	94	58	61	56	64	57	57
		0.1	a	29	96	94	95	93	93	89	63	30	50	52	62	75
			b	30	92	96	93	93	94	87	58	40	53	60	63	82
			c	31	97	89	96	95	NA	92	46	17	48	58	NA	91
			d	32	96	94	95	95	93	89	63	30	50	60	62	75

Notes:

m.v. pattern, Missing value pattern.

Var(ɛ), Variance of the random errors in the longitudinal submodel.

a₁, Fixed-effect slope in the longitudinal submodel.

D, Covariance matrix of the random effects in the longitudinal submodel. Refer to Table 1.

λ₁, Parameter for the effect of the time-dependent predictor on survival (true value = −0.03).

NA, Not available due to convergence problems.

Refer to Fig. 1 for other abbreviations.

Shading: 95% Confidence interval coverage < 90% or % estimates < true value is outside the interval [40, 60].

Table 2. Results of the estimation of λ1 from the 32 sets of simulations for which group effect is zero.