Table 1.
Neuropsychological and language test scores: mean values (range) and percentage of participants in each patient group who had a normal score (i.e., within the control range] for each test
| nfPPA (n = 9) |
svPPA (n = 14) |
lvPPA (n = 4) |
Controls (n = 22) | Omnibus significance | ||||
|---|---|---|---|---|---|---|---|---|
| mean (range) | % with Normal scores | mean (range) | % with normal scores | mean (range) | % with normal scores | |||
| Demographics | ||||||||
| Age | 69.1 (53–83) | 67.1 (59–81) | 64.3 (50–84) | 68.0 (54–83) | n.s. | |||
| Years of education | 13.4 (8–18) | 17.4 (10–28) | 15.5 (11–20) | 16.7 (10–25) | n.s. | |||
| Sex M:F | 6:3 | 9:5 | 2:2 | 12:10 | ||||
| Handedness L:R | 0:9 | 1:13 | 0:4 | 1:21 | ||||
| Years since first symptom | 3.3 (1.7–6.6) | 5.9 (2.5–12.3) | 7.1 (5.3–9.4) | n.a. | * | |||
| General cognitive function | ||||||||
| Mini-mental state examination, /30 | 21.2 (5–28)a | 22 | 23.3 (5–29)a | 29 | 17.3 (12–26)a | 0 | 29.0 (27–30) | *** |
| Nonverbal reasoning | ||||||||
| Raven's colored progressive matrices, /36 | 25.8 (10–36)a | 89 | 30.6 (22–36) | 100 | 22.0 (14–26)a | 75 | 31.9 (16–36) | * |
| Visuospatial skills | ||||||||
| Rey complex figure copy, /36 | 25.6 (14.5–36)a | 56 | 33.4 (29–36) | 93 | 21.9 (3.5–33)a | 25 | 33.5 (31–36) | ** |
| Cube analysis test, /10 | 9.3 (8–10) | 100 | 9.4 (4–10) | 100 | 5.0 (0–7)a | 75 | 8.9 (3–10) | ** |
| Nonverbal episodic memory | ||||||||
| Rey complex figure recall, /36 | 12.4 (5.5–21)a | 44 | 10.6 (0–26)a | 43 | 7.8 (2–16)a | 50 | 18.4 (9.5–29) | ** |
| Recognition memory test for faces, /25 | 23.0 (20–25) | 100 | 18.1 (12–25)a | 43 | 18.0 (15–20) | 50 | 24.2 (19–25) | *** |
| Language and semantics | ||||||||
| WAB aphasia quotient, /100 | 76.7 (21–95.4)a | 11 | 79.9 (43.9–95.0)a | 7 | 80.9 (70.5–92.5) | 25 | 99.1 (92.4– 100) | *** |
| Boston naming test, /60 | 34.2 (0–56)a | 44 | 14.6 (0–35)a | 0 | 33.8 (19–55) | 25 | 55.1 (42–60) | *** |
| Test for the reception of grammar, /80 | 61.4 (44–76)a | 22 | 68.6 (25–79)a | 57 | 53.0 (41–65)a | 0 | 78.1 (73–80) | *** |
| Peabody picture vocabulary test, /204 | 167.0 (117–185)a | 78 | 111.6 (12–176)a | 7 | 160.8 (112–191)a | 50 | 193.6 (163–201) | *** |
| Pyramids & palm trees - picture version, /52 | 47.2 (44–51)a | 44 | 44.3 (33–51)a | 43 | 45.3 (37–51)a | 50 | 50.8 (47–52) | *** |
| Sentence anagrams with pictures, /20 | 16.5 (10–20)a | 20 | 18.4 (9–20)a | 79 | 17.3 (13–20)a | 25 | 20.0 (20–20) | *** |
| Repeat & point test - repetition, /10 | 7.2 (0–10)a | 33 | 8.9 (7–10)a | 71 | 9.0 (8–10)a | 50 | 9.9 (9–10) | *** |
| Repeat & point test - pointing, /10 | 8.5 (8–10) | 30 | 5.2 (l–7)a | 21 | 8.0 (7–10) | 100 | 9.0 (7–10) | *** |
Asterisks denote significant effect of group on the Kruskal-Wallis test at * p < 0.05, ** p < 0.01, *** p < 0.001.
a
Significantly different from normal controls (Mann-Whitney U tests, one tailed, p < 0.05).