Table 4.

Classification of individuals with nfPPA with respect to MRI volumetric data for key brain regions

Interpretation of atrophy pattern	Patient/case No.	Length of history, years	WAB aphasia quotient, /100	Frank grammatism?	AOS?	Brain region
						left inferior frontal	left insula	left anterior temporala	left posterior temporal	left inferior parietal
Imaging supported diagnosis of nfPPA (n = 6)
	44	2.3	95.4	no	no	−1.68	−3.27	−1.88	−0.98	−1.30
	17	4.3	88.0	no	no	0.48	−2.03	−2.15	−1.44	−1.31
	31	1.7	86.4	no	no	−3.01	−3.47	−4.94	−1.57	−1.75
	8	3.8	82.6	no	no	−2.48	0.32	−1.22	−0.72	−0.53
	32	2.1	81.4	no	no	−2.03	−3.48	−8.58	−1.45	−0.03
	18	3.9	21.0	yes	yes	−3.69	−3.15	−2.47	−1.78	−1.12
	mean:	3.5	78.5			−2.12	−2.53	−4.18	−1.42	−1.00
Cannot rule out lvPPA on the basis of MRI data (n = 3)
	22	2.3	86.8	no	no	−2.42	−2.11	−2.03	−1.96	−2.61
	37	3.3	79.2	no	no	0.07	−3.04	−1.79	−2.14	−1.89
	36	6.6	69.4	yes	yes	−3.58	−4.48	−3.47	−3.02	−3.53
	mean:	3.7	73.5			−2.02	-2.63	-2.11	−2.05	−2.54

Volumetric data are presented as z-scores and those which are considered abnormal appear in bold (i.e., z-scores below −2.0). Patients are ordered within each group by their WAB aphasia quotients.

^aThe significant left anterior temporal atrophy shown by some patients presumably arose because the area examined includes some of the anterior superior perisylvian region.