Table 2.
Comparative antimicrobial activity of ancestral and extant tick defensins.
| Defensins | ||||||||
| Microorganisms | STiDA | DefMT2∗ | DefMT3∗ | DefMT5∗ | DefMT6∗ | DefMT7∗ | Scapularisin-3∗∗ | Scapularisin-6∗∗ |
|---|---|---|---|---|---|---|---|---|
| Bacteria Gr+ | ||||||||
| Listeria monocytogenes | - | - | + | + | + | - | - | - |
| L. fleischmannii | - | - | + | + | + | - | - | - |
| L. grayi | - | - | + | + | + | - | - | + |
| L. marthii | - | - | - | - | - | - | - | - |
| L. innocua | - | - | - | - | - | - | - | - |
| L. welshimeri | - | - | - | - | - | - | - | - |
| L. seeligeri | - | - | + | + | + | - | - | - |
| Staphylococcus Aureus | - | - | + | + | + | - | - | - |
| S. epidermidis | - | - | - | - | + | - | - | - |
| Bacteria Gr- | ||||||||
| Escherichia coli | - | - | - | - | + | - | - | - |
| Pseudomonas Aeruginosa | - | - | + | + | + | - | - | - |
| Fungi | ||||||||
| Fusarium culmorum | NT | - | + | + | + | - | + | + |
| F. graminearum | NT | - | + | + | + | - | + | + |
| Apicomplexan | ||||||||
| Plasmodium falciparum | + | + | + | + | - | + | NT | NT |
∗Data collected from (Tonk et al., 2015). ∗∗Data collected from (Tonk et al., 2014a). ‘NT’ not tested. ‘+’ activity. ‘-’ no activity.