Table 1. Characteristics of the oligonucleotides used in simulations.
| Sequence, 5′-3′ | nr./position (LNAs) | Length (nt) | Base content |
|---|---|---|---|
| Sequences used in molecular modelling | |||
| SEQ1: TCC + TCT CTT TCT + CTT TCT + CTT | 3/4, 13, 19 | 21 | 62% T, 38% C |
| SEQ2: ATT + TAT TTT + TAT ATT TAT + ATT | 3/4, 10, 19 | 21 | 71% T, 29% A |
| SEQ3: TGA ACT + CTA TGT + CTG TAT + CAT | 3/7, 13, 19 | 21 | 43% T, 24% A 19% C, 14% G |
| SEQ4: TCC + TCT CTT + TCT + CTT TCT + CTT | 4/4, 10, 14, 19 | 21 | 62% T, 38% C |
| SEQ5: TCC TCT CTT TCT CTT TCT CTT | 0/− | 21 | 62% T, 38% C |
The five oligonucleotides have different sequences and additional LNA in SEQ1-SEQ4*.
*Pluses indicate LNA modifications. Bold indicate docking bases.