Table 2. Multivariate Cox proportional hazard analysis of CDC25C gene expression for bladder cancer patients undergoing radical cystectomy.

Data set	Covariate	HR	95% CI	P-value
MD Anderson (n = 37)	CDC25C	2.26	1.04–5.40	0.0382
	T3,4 vs. T1,2	4.08	0.98–28.7	0.0536
	N+ vs. N0	1.2	0.39–4.22	0.7594
Chungbuk (n = 135)	CDC25C	1.68	1.03–2.70	0.0396
	T3,4 vs. T1,2	6.98	2.56–16.9	0.0004
	N+ vs. N0	1.43	0.37–4.90	0.584
Lund (n = 224)	CDC25C	2.27	1.05–4.77	0.038
	T3,4 vs. T1,2	5.86	1.92–14.9	0.0037

Pathologic tumor and nodal stages and CDC25C gene expression were included as covariates for bladder cancer patients undergoing radical cystectomy without perioperative chemotherapy. Tumor stage and nodal stage were considered binary variables; CDC25C gene expression was considered a continuous variable. HR, hazard ratio; 95% CI, confidence interval. Nodal staging was excluded from analysis of the Lund data set due to insufficient data.