Table 1.

Studies of intravenous thrombolytic therapy in acute ischemic stroke with ICA occlusion

Study	Treatment	Patients, n	Favorable outcome, definition	Favorable outcome, n (%)	Mortality, n (%)	sICH, n (%)
ICARO 17, 2012	IV tPA within 4.5 h	253	mRS 0–2 at 3 mo.	73 (29)	65 (26)	12 (5)
ICARO-2 18, 2012	IV tPA within 4.5 h	134	mRS 0–2 at 3 mo.	43 (32.1)	30 (22.4)	8 (5.8)
ICARO-3 26, 2015	IV tPA within 4.5 h	324	mRS 0–2 at 3 mo.	89 (27.4)	75 (23.1)	n.a.
EPITHET 16, 2010	IV tPA within 6 h	13	mRS 0–2 at 3 mo.	0 (0)	n.a.	n.a.
CLOTBUST 22, 2007	IV tPA within 3 h	25	mRS 0–2 at 3 mo.	5 (20)	7 (28)	3 (12)
Endo 3, 1998	IV UK or tPA within 6 h	12	mRS 0–2 at 1 mo.	0 (0)	9 (75)	0 (0)

UK = Urokinase; mo = months; n.a. = not available.