Table 2.
Studies of IA therapy in acute ischemic stroke with ICA occlusion
| First author [ref.], year | Treatment | Patients, n | Successful recanalization, definition | Successful recanalization, n (%) | Favorable outcome, definition | Favorable outcome, n (%) | Mortality, n (%) | sICH n (%) |
|---|---|---|---|---|---|---|---|---|
| Cohen 11, 2015 | IV tPA, angioplasty, stent, stent retriever | 24 | TIMI 3 | 19 (79) | mRS score 0–2 at 3 mo. | 13 (76) | 2 (8) | 0 (0) |
| Heck 30, 2015 | IV tPA, stent, mechanical thrombectomy | 23 | TICI 2b/3 | 17 (74) | mRS score 0–2 at 3 mo. | 12 (52) | 9 (39) | 5 (22) |
| Lockau 31, 2015 | IV tPA, angioplasty, stent, stent retriever | 37 | TICI 2b/3 | 27 (73) | mRS score 0–2 at 3 mo. | 17 (45.9) | 7 (18.9) | 4 (10.8) |
| Puri 32, 2015 | IV tPA, angioplasty, stent, stent retriever | 28 | TICI 2b/3 | 20 (71.4) | mRS score 0–2 at 3 mo. | 11 (39.3) | 4 (14.3) | 2 (7.1) |
| Lescher 34, 2015 | IV tPA, angioplasty, stent, stent retriever | 39 | TICI 2b/3 | 25 (64) | mRS score 0–2 at 3 mo. | 14 (36) | 4 (10) | 4 (10) |
| Stampfl 12, 2014 | IV tPA, angioplasty, stent, stent retriever | 24 | TICI 2b/3 | 15 (62.5) | mRS score 0–2 at 3 mo. | 7 (29.2) | 4 (16.6) | 4 (16.6) |
| Paciaroni 25, 2015 | IA tPA or UK, stent, mechanical, thrombectomy | 324 | TICI 2/3 | 182 (68.7) | mRS score 0–2 at 3 mo. | 105 (32.4) | 57 (17.6) | n.a. |
| Woodward 36, 2014 | IV tPA, aspiration, stent retriever | 7 | TICI 2b/3 | 7 (100) | mRS score 0–2 at 3 mo. | 6 (85.7) | 1 (14.3) | 0 (0) |
| Mpotsaris 10, 2013 | IV tPA, stenting, mechanical thrombectomy | 41 | TIMI 2/3 | 35 (85) | mRS score 0–2 at 3 mo. | 15 (37) | 15 (37) | 3 (7) |
| Fischer 33, 2013 | IV or IA tPA, angioplasty, mechanical thrombectomy | 201 | TIMI 2/3 | 157 (78) | mRS score 0–2 at 3 mo. | 54 (28) | 60 (29.9) | 12 (6) |
| Dababneh 28, 2012 | IV tPA, angioplasty, mechanical thrombectomy | 2 | TICI 2/3 | 2 (100) | mRS score 0–2 at 2 mo. | 2 (100) | 0 (0) | 0 (0) |
| Papanagiotou 29, 2011 | IV tPA, stent, penubra/stent retriever | 22 | TIMI 2/3 | 21 (95) | mRS score 0–2 at 3 mo. | 9 (41) | 3 (14) | 4 (18) |
| Ozdemir 38, 2008 | IA tPA | 8 | TIMI 2/3 | 6 (75) | mRS score 0–2 at 3 mo. | 8 (100) | 0 | 0 |
| Zaidat 4, 2002 | IA tPA or UK, mechanical thrombectomy | 18 | n.a. | n.a. | mRS score 0–2 at 3 mo. | 6 (33) | 9 (50) | 3 (17) |
| Endo 3, 1998 | IA tPA or UK, angioplasty | 21 | successful | 8 (38) | mRS score 0–2 at 1 mo. | 5 (24) | 10 (48) | 1 (5) |
TIMI = Thrombolysis in myocardial infarction; UK = urokinase; mo = months; n.a. = not available.