Table 1. Studies comparing living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC).
Author | LDLT vs. DDLT | Country | Year | Study period | Type of LT | Case number | Recurrence free survival | Criteria used | Outside Milan (%) | Difference in tumor characteristics | Median follow-up period (months) | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-year | 3-year | 5-year | P | |||||||||||
Hu et al. (15) | LDLT > DDLT | China | 2015 | 1999−2009 | LDLT | 389 | 78 | 64 | 62 | <0.001 | Hangzhou criteria | 6 | More aggressive in DDLT | 16 |
DDLT | 6,471 | 66 | 49 | 42 | 4 | 15 | ||||||||
Ninomiya et al. (16) | LDLT = DDLT | Japan (LDLT); USA (DDLT) | 2015 | 2002−2010 | LDLT | 133 | 92 | 86 | 85 | NS | Kyushu criteria | 41 | More aggressive in LDLT | 76 |
DDLT | 362 | 94 | 86 | 81 | Milan | 34 | 67 | |||||||
Xiao et al. (17) | LDLT = DDLT | China | 2014 | 1999−2012 | LDLT | 84 | 85 | 56 | 53 | NS | Hangzhou criteria | 69 | None | 27 |
DDLT | 276 | 73 | 49 | 45 | 72 | |||||||||
Park et al. (18) | LDLT < DDLT | Korea | 2014 | 1999−2010 | LDLT | 166 | 89 | − | 81 | 0.045 | UCSF | NA | None | 35 |
DDLT | 50 | 96 | − | 94 | ||||||||||
Sandhu et al. (19) | LDLT = DDLT | Canada | 2013 | 1996−2009 | LDLT | 58 | 88 | 75 | 70 | NS | Toronto criteria | 28 | None | 38 |
DDLT | 287 | 86 | 75 | 70 | 32 | 31 | ||||||||
Kulik et al. (20) | LDLT < DDLT | USA | 2012 | 1998−2010 | LDLT | 100 | 80 | 66 | 56 | 0.05 | UNOS | 59 | More aggressive in LDLT | 60 |
Multi-center | DDLT | 97 | 90 | 81 | 73 | 30 | ||||||||
Bhangui et al. (10) | LDLT = DDLT | France | 2011 | 2000−2009 | LDLT | 36 | 100 | 89 | 88 | NS | UCSF | 27 | None | 58 |
DDLT | 120 | 93 | 89 | 86 | 21 | 50 | ||||||||
Li et al. (14) | LDLT = DDLT | China | 2010 | 2005−2009 | LDLT | 38 | 71 | 42 | − | NS | UCSF | 79 | None | 25 |
DDLT | 101 | 76 | 41 | − | 68 | |||||||||
Di Sandro et al. (13) | LDLT = DDLT | Italy | 2009 | 2000−2007 | LDLT | 25 | − | 96 | 96 | NS | Milan | 20 | None | − |
DDLT | 154 | − | 91 | 89 | 31 | |||||||||
Sotiropoulos et al. (21) | LDLT = DDLT | Germany | 2007 | 1998−2006 | LDLT | 45 | 88 | 75 | − | NS | UCSF | 44 | None | − |
DDLT | 55 | − | 81 | − | − | |||||||||
Lo et al. (22) | LDLT < DDLT | Hong Kong | 2007 | 1995−2004 | LDLT | 43 | 93 | 71 | 71 | 0.029 | UCSF | 26 | More aggressive in LDLT | 33 |
DDLT | 17 | 100 | 100 | 100 | 29 | |||||||||
Hwang et al. (23) | LDLT = DDLT | Korea | 2005 | 1992−2002 | LDLT | 237 | 83 | 80 | − | NS | − | 27 | None | 26 |
Multi-center | DDLT | 75 | 88 | 82 | − | 29 | 45 | |||||||
Gondolesi et al. (3) | LDLT = DDLT | USA | 2004 | 1988−2002 | LDLT | 36 | 82 | 74 | − | NS | UNOS | 53 | None | 15 |
DDLT | 165 | 90 | 83 | − | − |
DDLT, deceased donor liver transplantation; HCC, hepatocellular carcinoma; LDLT, living donor liver transplantation; LT, liver transplantation; UCSF, the University of California, San Francisco; UNOS, United Network for Organ Sharing