Table 1. The main features of included studies for PAX1 and SOX1 methylation in diagnosing cervical cancer.
| Author | Year | Study population | Patient size | Control size | Specimen type | HPV type | Method | Cut-off value (PMR %) | |
|---|---|---|---|---|---|---|---|---|---|
| Total | HSIL/CIN3+/cancer | ||||||||
| Chao et al. (16) | 2013 | Taiwanese | 58 | 8 | 50 | Cervical scrapings | High-risk | QMSP | PAX1: 27 |
| Chang et al. (22) | 2015 | Taiwanese | 126 | 66 | 10 | Cervical swabs/tissues | – | QMSP | PAX1: 1.4; SOX1: 15.6 |
| Kan et al. (17) | 2014 | Taiwanese | 172 | 36 | 247 | Cervical scrapings | High-risk | QMSP | PAX1: 11 |
| Lai et al. (12) | 2008 | Taiwanese | 125 | 80 | 45 | Cervical swabs | High-risk | QMSP | Unclear |
| Lai et al. (15) | 2010 | Taiwanese | 132 | 66 | 53 | Cervical scrapings | – | QMSP | PAX1: 10.17; SOX1: 1.8 |
| Lai et al. (14) | 2014 | Taiwanese | 266 | 141 | 410 | Cervical swabs | High-risk type involved 16, 18 | QMSP | PAX1: 4.88 |
| Li et al. (23) | 2015 | Chinese | 34 | 34 | 429 | Cervical scrapings | High-risk | MS-HRM | Unclear |
| Wang et al. (13) | 2014 | Chinese | 91 | 31 | 39 | Cervical scrapings | High-risk | MS-HRM | PAX1: 10 |
| Xu et al. (19) | 2013 | Chinese | 72 | 41 | 20 | Cervical swabs/biopsy tissues | High-risk | QMSP | PAX1: 25 |
| Zhou et al. (18) | 2011 | Chinese | 80 | 42 | 10 | Cervical scrapings | – | QMSP/MS-HRM | Unclear |
| Huang et al. (20) | 2010 | Taiwanese | 56 | 28 | 17 | Cervical scrapings | High-risk | QMSP | PAX1: 4.5 |
PAX1, paired boxed gene 1; SOX1, sex determining region Y-box 1; QMSP, quantitative methylation-specific polymerase chain reaction; MS-HRM, methylation-sensitive high-resolution melting; PMR, percentage of methylated reference; HSIL, high-grade squamous intraepithelial lesion; HPV, human papillomavirus.