Table 2. Diagnostic indices of PAX1 and SOX1 methylation for cervical cancer screening.

Analysis	Pooled sensitivity (95% CI)	Pooled specificity (95% CI)	Pooled PLR (95% CI)	Pooled NLR (95% CI)	Pooled DOR (95% CI)	AUC
PAX1	0.73 (0.70–0.75)	0.87 (0.85–0.89)	5.80 (5.04–6.68)	0.30 (0.23–0.38)	27.51 (17.24–43.88)	0.91
SOX1	0.71 (0.67–0.74)	0.64 (0.61–0.67)	2.69 (1.77–4.09)	0.36 (0.23–0.55)	8.73 (5.75–13.27)	0.82
HPV	0.81 (0.77–0.85)	0.70 (0.67–0.72)	2.31 (1.78–2.99)	0.32 (0.20–0.51)	8.18 (4.15–16.12)	0.77
PAX1/HPV	0.75 (0.73–0.78)	0.81 (0.79–0.82)	3.93 (3.15–4.91)	0.28 (0.22–0.35)	20.49 (14.02–29.93)	0.89
SOX1/HPV	0.64 (0.58–0.69)	0.48 (0.45–0.52)	2.22 (1.52–3.26)	0.34 (0.17–0.71)	11.32 (5.39–23.80)	0.84
PAX1/SOX1	0.72 (0.69–0.74)	0.77 (0.76–0.79)	5.41 (3.50–8.36)	0.29 (0.22–0.39)	21.41 (13.78–33.28)	0.89
Outlier excluded for PAX1	0.74 (0.71–0.77)	0.86 (0.83–0.88)	5.59 (4.82–6.48)	0.27 (0.19–0.38)	29.84 (17.72–50.24)	0.92
Outlier excluded for HPV	0.84 (0.80–0.88)	0.70 (0.68–0.73)	2.36 (1.78–3.12)	0.29 (0.17–0.50)	9.30 (4.39–19.69)	0.79

No outlier studies identified in SOX1 methylation test. PAX1, paired boxed gene 1; SOX1, sex determining region Y-box 1; CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve.