Table 2. Genotype and allele frequencies of IL-18Rap and IL-37 polymorphisms in BD and healthy controls.

Gene	SNPs	Stage	Genotype Allele	BD		Controls		P Value	Pc Value	OR(95% Cl)
				N	%	N	%
IL-37	rs3811047	First	AA	13	3.1	16	2.6	0.581	NS	1.232(0.586–2.589)
			AG	92	22.1	221	35.2	6.00 × 10–6	4.32 × 10−4	0.522(0.393–0.693)
			GG	311	74.8	390	62.2	2.30 × 10−5	1.66 × 10−3	1.800(1.369–2.367)
			G	714	85.8	1001	79.8	4.57 × 10−4	2.19 × 10−2	1.529(1.205–1.942)
			A	118	14.2	253	20.2	4.57 × 10−4	2.19 × 10−2	0.654(0.515–0.830)
		Second	AA	9	1.4	50	4	0.002	NS	0.337(0.165–0.690)
			AG	141	21.8	365	29.3	4.52 × 10−4	3.25 × 10−2	0.672(0.528–0.840)
			GG	497	76.8	830	66.7	5.00 × 10−6	3.60 × 10−4	1.657(1.333–2.059)
			G	1135	87.7	2025	81.3	5.10 × 10−7	2.45 × 10−5	1.639(1.350–1.990)
			A	159	12.3	465	18.7	5.10 × 10−7	2.45 × 10−5	0.610(0.502–0.741)
		Combined	AA	22	2.1	66	3.5	0.026	NS	0.578(0.355–0.943)
			AG	233	21.9	586	31.3	5.10 × 10−8	3.67 × 10−6	0.616(0.517–0.734)
			GG	808	76	1220	65.2	1.01 × 10−9	7.27 × 10−8	1.693(1429–2.007)
			G	1849	87	3026	80.8	1.60 × 10−9	7.68 × 10−8	1.584(1.363–1.841)
			A	277	13	718	19.2	1.60 × 10−9	7.68 × 10−8	0.631(0.543–0.734)
IL-18RAP	rs2058660	First	AA	89	21.4	195	31.1	5.64 × 10−4	2.08 × 10−2	0.603(0.452–0.805)
			AG	194	46.6	289	46.1	0.863	NS	1.022(0.797–1.310)
			GG	133	32	143	22.8	0.001	NS	1.591(1.205–2.100)
			A	372	44.7	679	54.1	2.44 × 10−5	1.17 × 10−3	0.685(0.574–0.817)
			G	460	55.3	575	45.9	2.44 × 10−5	1.17 × 10−3	1.460(1.224–1.741)
		Second	AA	124	19.2	344	27.6	5.20 × 10−5	3.74 × 10−3	0.621(0.492–0.783)
			AG	346	53.5	603	48.4	0.037	NS	1.224(1.012–1.480)
			GG	177	27.3	298	24.0	0.104	NS	1.197(0.964–1.486)
			A	594	45.9	1291	51.8	5.23 × 10−4	2.51 × 10−2	0.788(0.689–0.902)
			G	700	54.1	1199	48.2	5.23 × 10−4	2.51 × 10−2	1.269(1.109–1.452)
		Combined	AA	213	20	539	28.8	1.77 × 10−7	1.27 × 10−5	0.620(0.517–0.742)
			AG	540	50.8	892	47.6	0.101	NS	1.134(0.976–1.319)
			GG	310	29.2	441	23.6	8.24 × 10−4	NS	1.336(1.127–1.583)
			A	966	45.4	1970	52.6	1.24 × 10−7	5.94 × 10−6	0.750(0.674–0.834)
			G	1160	54.6	1774	47.4	1.24 × 10−7	5.94 × 10−6	1.334(1.198–1.484)

SNP = single-nucleotide polymorphism; BD = 5% confidence interval; Pc = Bonferroni corrected p value.