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. 2016 Oct 24;6:35874. doi: 10.1038/srep35874

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Fold changes in CDC6 or CHEK1 mRNA expression in human tumours compared to normal tissue controls were determined using the Firehose analysis tool from the Broad Institute TCGA Genome Data Analysis Center. (b) The correlation between CHEK1 (Chk1) and CDC6 mRNA expression levels was determined from publicly available datasets in colon, HCC, lung and ovarian tumours. (c) Model of ATR-Chk1 counterbalance to Cdc6 overexpression-induced origin hyperactivation and replication stress in human cancer.