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In cells stimulated with fibronectin, a subcellular pool of PKD1 localizes to FAs where it induces FA maturation and blocks FA turnover. This is mediated by PKD1 phosphorylation of FA-localized PIP5Klγ at serine 448 which occurs in response to Integrin-RhoA signaling. S448 phosphorylation inhibits PIP5Klγs’ binding affinity for Talin and its lipid kinase activity which in turn leads to increased cellular adhesion.
