Figure 4. Comparisons among the prior pathway and two learned pathways.

(a) The prior knowledge pathway was derived by removing unidentifiable proteins in the original network published for the DREAM 4 challenge²⁴. The width of each edge is proportional to its prior confidence score. (b) The signaling pathway learned by our method in which the green edges were inferred and added into the prior network. (c) The signaling pathway learned in ref. 19 in which the green edges were inferred although not in the prior network. (d) The curves of the best LSE and model complexity (measured by the number of edges) with regard to γ, as well as the LSE and MSE values for the measured proteins.