Figure 5. Predictions of cell fates by prior and learned networks.

(a) Prior signaling network derived from two manually curated signaling pathways proposed in our previous studies³⁶,³⁷. The black and red edges represent interactions of types activation and inhibition, and green edges represent feedback interactions. (b) Network inferred by using the phosphoproteomic time-series data of the E → D treated BT-20 cell line. (c) Dynamic curves of three cell fates, i.e. apoptosis, proliferation and cell cycle arrest, corresponding to experimental observations, the predictions by the prior network and trained network, respectively.