Table 1.
List of fungal virulence factors found in Exophiala dermatitidis.
| Function | Species | Gene | Homolog | Type of homology | DEG (fdr;fold) Rank | References |
|---|---|---|---|---|---|---|
| Shape | Candida albicans | Hgc1 | HMPREF1120_04169 | B:4·10−12,PD:6·10−35 | 0.012; 3.13 | Mayer et al., 2013 |
| Exophiala dermatitidis | Efg1 StuA | HMPREF1120_05541 | B:4·10−168 | 0.0037; 7.01 | Ye and Szaniszlo, 2000 | |
| Adherence | Aspergillus fumigatus | AfCalAp | HMPREF1120_05161 | B:1·10−23,PD:1.5·10−4 | Upadhyay et al., 2009 | |
| HMPREF1120_03984 | B:7·10−13,PD:5.1·10−9 | |||||
| HMPREF1120_05769 | PD:2.22·10−48 | |||||
| Candida albicans | Ecm33 | HMPREF1120_03851 | B:6·10−49 | Martinez-Lopez et al., 2006 | ||
| Candida albicans | Phr1 | HMPREF1120_03477 | B:7·10−177 | Calderon et al., 2010 | ||
| HMPREF1120_07283 | B:1·10−85 | 85 | ||||
| HMPREF1120_01763 | B:4·10−84 | |||||
| HMPREF1120_01682 | B:2·10−66 | |||||
| Microsporum canis | Sub3 | HMPREF1120_08439 | B:2·10−75 | Baldo et al., 2010 | ||
| Protease | Candida albicans | Sap1-10 | HMPREF1120_00212 | PD:8·10−93 B:8·10−19 | Mayer et al., 2013 | |
| HMPREF1120_00818 | PD:3·10−77 B:3·10−16 | |||||
| HMPREF1120_01981 | PD:5·10−6 | |||||
| HMPREF1120_03062 | PD:8·10−19 | |||||
| HMPREF1120_03766 | PD:2·10−81 B:3·10−26 | |||||
| HMPREF1120_05067 | PD:3·10−22 | |||||
| HMPREF1120_05119 | PD:9·10−90 B:7·10−61 | |||||
| HMPREF1120_06343 | PD:3·10−115 B:4·10−33 | |||||
| HMPREF1120_06360 | PD:7·10−77 B:9·10−46 | |||||
| HMPREF1120_06819 | PD:9·10−74 B:2·10−14 | |||||
| HMPREF1120_07351 | PD:6·10−36 | |||||
| HMPREF1120_08062 | PD:7·10−76 B:1·10−46 | |||||
| asmbl_11606|m.22873 | PD:8·10−25 | |||||
| Trychomyces rubrum | Ssu1 | HMPREF1120_04816 | B:5·10−115 | 0.046; 0.40 | Léchenne et al., 2007 | |
| Invasion | Cryptococcus neoformans | Plb1 | HMPREF1120_00190 | B:6·10−100 | Noverr et al., 2003 | |
| HMPREF1120_06300 | B:1·10−61 | |||||
| Candida albicans | Ssa1 (Hsp70) | HMPREF1120_01564 | B:0 | 0.0043;6.19 | Sun et al., 2010 | |
| HMPREF1120_02459 | B:4·10−30 | 0.025;3.24 | ||||
| HMPREF1120_02626 | B:0 | 7 | ||||
| HMPREF1120_04200 | B:1·10−61 | 0.003;14.02 | ||||
| HMPREF1120_07756 | B:0 | 0.004;30.06/28 | ||||
| HMPREF1120_08142 | B:0 | 0.016;4.02/81 | ||||
| HMPREF1120_09114 | B:3·10−80 | |||||
| Exophiala dermatitidis | StuA | See above | ||||
| Biofilm | Aspergillus fumigatus | Laea | HMPREF1120_06677 | B:1·10−72 | Fanning et al., 2012 | |
| HMPREF1120_03377 | B:1·10−57 | |||||
| HMPREF1120_07722 | B:2·10−57 | |||||
| HMPREF1120_08797 | B:3·10−55 | |||||
| HMPREF1120_02912 | B:2·10−51 | |||||
| HMPREF1120_08429 | B:3·10−49 | |||||
| HMPREF1120_01429 | B:3·10−43 | |||||
| HMPREF1120_08930 | B:1·10−40 | |||||
| HMPREF1120_05890 | B:2·10−37 | |||||
| HMPREF1120_05291 | B:5·10−32 | |||||
| HMPREF1120_02485 | B:8·10−24 | |||||
| Candida albicans | Efg1 | HMPREF1120_05541 | B:6·10−57 | 9.31·10−5; 7.01 | Dieterich et al., 2002 | |
| Candida albicans | Bgl2 | HMPREF1120_04141 | B:7·10−51 | Taff et al., 2012 | ||
| Candida albicans | Phr1 | See above | ||||
| Candida albicans | Exg1 | HMPREF1120_04506 | B:1·10−109 | Taff et al., 2012 | ||
| HMPREF1120_06180 | B:2·10−62 |
Genes with at least one homolog in Exophiala dermatitidis are reported. Each entry contains the function, the original organism, the gene name, the corresponding homolog in Exophiala dermatitidis, the homology type (B, Blast E-value; PD, protein domain SUPERFAMILY E-value), the regulation factor, in case it is significant, and/or the expression level of the gene if it belongs to the top 100 expressed genes in the skin experiment and a reference.