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. 2016 Oct 24;6:35759. doi: 10.1038/srep35759

Figure 4. Selection pressure on two major B19 genes encoding NS1 and VP1 proteins.

Figure 4

Legend for Fig. 4: Red bars - non-neutral selection identified as pervasive in any of used statistical approach with P < 0.1; green bars - non-neutral selection identified as episodic by MEME with P < 0.1; X-axis represents codon positions; normalized dN-dS value obtained by SLAC method presented on Y-axis. Fig. 4a) NS1 gene (codons 18–671), particular NS1 protein domains highlighted: RI motif - replication-initiator motif: codons 79–147; NTP-binding and helicase domains: codons 320–416; putative transactivation domains: TAD1: codons 416–424; TAD2: codons 523–531; TAD3: codons 566–576; Fig. 4b) VP1 gene, including distinct protein parts uVP1 (codons 1–227) and VP2 (codons 227–742) and domains: vPLA2 (codons 130 to 195); GBM - globoside-binding motif (codons 577–677).