Table 1. B19 genotype 1 nucleotide substitution rate.

Data seta	analyzed partitions (nt)b	Clock modelc	Log Marginal Likelihoodd	Nucleotide substitution rate (10−4 substitutions/site/year)
				Mean ± S.E.	HPD
cDNA	665–4851	Relaxed exponential	−17913
substitution model	TIM3 + I + G	Relaxed lognormal	−18250
		Strict	−16535	1.03 ± 0.01	0.56–1.27
NS1	667–2631	Relaxed exponential	−8935
substitution model	TIM3 + I + G	Relaxed lognormal	−8925
		Strict	−7965	1.36 ± 0.01	0.73–1.75
VP1	2624–4851	Relaxed exponential	−10604
substitution model	TIM3 + I + G	Relaxed lognormal	−10606
		Strict	−9658	1.64 ± 0.01	1.00–2.00
uVP1	2624–3305	Relaxed exponential	−3836
substitution model	TPM3 + I + G	Relaxed lognormal	−3837
		Strict	−2847	1.11 ± 0.03	0.04–3.10
VP2	3305–4851	Relaxed exponential	−8448
substitution model	TrN + I + G	Relaxed lognormal	−8476
		Strict	−7486	2.32 ± 0.01	1.53–2.86

^a131 isolates used in analyses listed in Table S1a.

^bnumbered according to the reference sequence NC_000883.2.

^ccoalescent tree prior for all analyses was Bayesian Skygrid.

^dLog Marginal Likelihood obtained using Stepping Stone Sampling; Abbreviations: HPD - Highest Posterior Density interval contains 95% of posterior probability distribution of nucleotide substitution rate, S.E. – standard error of mean.