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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Neuropharmacology. 2016 Sep 12;111:242–252. doi: 10.1016/j.neuropharm.2016.09.011

Figure 7. Stimulation with rapid-acting antidepressants increases dendrite complexity in neuronal cortical culture.

Figure 7

Cortical cultures were incubated with AAV2-GFP on DIV3 to label neurons for morphological analysis. On DIV 17, cells were incubated with ketamine, LY341495, or GLYX-13 for 24 hr. Cells were fixed and imaged for GFP signal. Representative images of labeled cells are shown for each condition. Sholl analysis demonstrates that ketamine (a–c), LY 341495 (d–f), or GLYX-13 (g–i) increase dendrite complexity of cultured neurons. All results are presented as mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.0005 compared to vehicle (Students t test).