Fig. 7.

Effect of dietary-induced biotin deficiency on the level of mRNA expression of IFN-γ (A) and TNF-α (B) in large intestinal mucosa. Data are means ± SE of at least 3 sets of mice. (*P < 0.05; **P < 0.01). Effect of dietary-induced biotin deficiency on mouse intestinal permeability is shown. Intestinal permeability was examined using 4-kDa FITC-dextran (C) as described in materials and methods. Data are means ± SE of 3 pairs of biotin-deficient mice and their pair-fed controls (**P < 0.01).