Cartoon summarizing altered mRNA expression in cellular elements of the descending duodenal mucosa in patients with IBS-D, based on nominal significance (P < 0.05) or statistical significance (q < 0.05: INADL, MAGI1, PPP2R5C, MAPKAPK5, TLR3, and IL-15) and including TPSBA1 (P < 0.10). TJ, tight junction; GC-C, guanylate cyclase; CFTR, cystic fibrosis transmembrane regulator. Fold upregulated mRNA is in black; downregulated is in gray.