FIGURE 1.
The figure shows schematically the translational aspects of this work. Specifically the top part of the figure describes the work of Dutoit et al. (7) of isolating glioma antigens expressed specifically in glioma tumor cells. The middle part of the figure illustrates how Rampling et al. () utilized these antigens to immunize patients. The lower part of the figure illustrates the mechanism of action whereby the antigens used as immunogens are transported to the draining lymph nodes where they are presented to naïve T-cells. The resulting T-effector cells then migrate to the tumor in the brain where they kill antigen expressing glioma cells.