Table1.

Target genes assessed in the compartmentalized micro multi-culture device. Target genes, known to be deregulated, in breast cancer were selected based on review of the literature. This panel includes gene targets involved in proliferation, angiogenesis, and invasion and migration in tumor development and progression

List of Target Genes
Function	Abbrev.	Encoded Protein	Ref.
Proliferation	TGFB1	Transforming Growth Factor Beta 1	(Tobin et al. 2002; Muraoka et al. 2002)
Ligand	FGF2	Basic Fibroblast Growth Factor	(Penault-Llorca et al. 1995)
	FGF1	Acidic Fibroblast Growth Factor	(Penault-Llorca et al. 1995; Yoshimura et al. 1998)
	HGF	Hepatocyte Growth Factor	(Tyan et al. 2011; Edakuni et al. 2001)
Angiogenesis	VEGFa	Vascular Endothelial Growth Factor A	(Weigand et al. 2005)
Ligand	PDGFα	Platelet-derived Growth Factor alpha	(Shao et al. 2000; Yu et al. 2015)
	PDGFβ	Platelet-derived Growth Factor beta	(Shao et al. 2000; Frings et al. 2013)
Invasion &	MMP9	Matrix Metalloproteinase 9	(Fleming et al. 2012; Nanda et al. 2013)
Migration	MMP3	Matrix Metalloproteinase 3	(Nozaki et al. 2000)
	MMP7	Matrix Metalloproteinase 7	(Fernandez-Garcia et al. 2014; DeLassus et al. 2011)
	MMP1	Matrix Metalloproteinase 1	(DeLassus et al. 2011; Boström et al. 2011)
Invasion	TIMP1	Tissue Inhibitor of Metalloproteinases 1	(Fernandez-Garcia et al. 2014; Peng et al. 2011)
Inhibitor	TIMP2	Tissue Inhibitor of Metalloproteinases 2	(Fernandez-Garcia et al. 2014; Hsu et al. 2012)
Proliferation	FGFR1	Fibroblast Growth Factor Receptor 1	(Penault-Llorca et al. 1995; Jacquemier et al. 1994)
Receptor	FGFR2	Fibroblast Growth Factor Receptor 2	(Sungeun Kim et al. 2013a, 2013b)
	TGFBR1	Transforming Growth Factor Beta Receptor 1	(Guido et al. 2012)
	TGFBR2	Transforming Growth Factor Beta Receptor 2	(Busch et al. 2015; Tobin et al. 2002)
	MET	Met Proto-oncogene	(Edakuni et al. 2001)
Angiogenesis	FLT1	FMS-related Tyrosine Kinase 1	(Weigand et al. 2005)
Receptor	KDR	Kinase Insert Domain Receptor	(Guo et al. 2010)