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. 2016 Oct 24;7:184. doi: 10.3389/fneur.2016.00184

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Copyright © 2016 Jang, Park, Chang, Pae and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Procedures for network analyses in the whole brain network (A) and motor subnetwork (B). The whole brain network is composed of 110 nodes in the cerebral cortex. Cross-correlation and partial cross-correlation of the time series across all nodes compose functional connectivity (FC) and partial-correlation functional connectivity (pFC) matrices at four time points: op − 1d, op + 1d, op + 7d, and op + 3m (1 day before operation, 1 day after operation, 7 days after operation, and 3 months after operation, respectively). The same procedure for functional network analysis was done within the motor subnetwork (B), except for structure–function coupling. The motor subnetwork includes the precentral gyrus, supplementary motor areas (SMA), putamen, thalamus, external globus pallidum, internal globus pallidum, subthalamic nucleus, substantia nigra, and red nucleus in the left hemisphere, and right dentate nucleus in the cerebellum.