Table 2.
Statistical result of network properties.
| Target | Longitudinal changes |
Correlation with CRST A scores (mixed effect model analysis) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Repeated-measures ANOVA | op − 1d | op + 1d | op + 7d | op + 3m | Post hoc (Tukey’s HSD) | Action | Posture | ||
| Behavior | CRST A score (action) | F(1.6,11.4) = 28.00, p = 0.000 | 2.87 (0.64) | – | 0.87 (0.83) | 0.87 (0.99) | op − 1d > op + 7d: p < 0.001 | – | – |
| op − 1d > op + 3m: p = 0.001 | |||||||||
| CRST A score (posture) | F(2,14) = 19.08, p = 0.000 | 2.25 (0.71) | – | 0.37 (0.74) | 0.63 (0.74) | op − 1d > op + 7d: p = 0.002 | – | – | |
| op − 1d > op + 3m: p < 0.001 | |||||||||
| Motor-tremor network | Left GPe-SN | F(3,21) = 7.73, p = 0.001 | 2.01 (1.11) | 0.95 (1.40) | 0.97 (2.19) | 3.02 (1.47) | op + 1d < op + 3m: p = 0.003 | F(1,14.70) = 9.00, p = 0.009 | F(1,17.01) = 6.38, p = 0.022 |
| op + 7d < op + 3m: p = 0.003 | |||||||||
| Right GPe-SN | F(3,21) = 10.30, p = 0.000 | 1.39 (1.24) | −0.25 (1.07) | 1.76 (1.55) | 2.81 (2.06) | op − 1d > op + 1d: p = 0.036 | N.S. | N.S. | |
| op + 1d < op + 3m: p = 0.000 | |||||||||
| op + 1d < op + 7d: p = 0.008 | |||||||||
| Average node degree | F(3,21) = 4.00, p = 0.021 | 3.88 (1.72) | 2.33 (0.83) | 2.48 (1.68) | 2.95 (1.08) | op − 1d > op + 1d: p = 0.024 | N.S. | F(1,17.38) = 12.24, p = 0.003 | |
| op − 1d > op + 7d: p = 0.045 | |||||||||
| Average node strength | F(3,21) = 3.72, p = 0.027 | 1.09 (0.48) | 0.68 (0.20) | 0.84 (0.52) | 0.93 (0.34) | op − 1d > op + 1d: p = 0.018 | F(1,15.20) = 4.34, p = 0.054 | F(1,13.98) = 5.39, p = 0.036 | |
| Global efficiency | F(3,21) = 3.52, p = 0.033 | 0.17 (0.05) | 0.12 (0.04) | 0.12 (0.07) | 0.14 (0.06) | op − 1d > op + 1d: p = 0.060 | F(1,15.39) = 8.01, p = 0.0124 | F(1,13.95) = 9.35, p = 0.008 | |
| op − 1d > op + 7d: p = 0.049 | |||||||||
| Node degree of left thalamus | N.S. | 5.25 (1.83) | 3.88 (1.55) | 3.38 (2.33) | 4.13 (1.46) | – | F(1,18.10) = 4.51, p = 0.048 | F(1,12.40) = 11.67, p = 0.005 | |
| Whole brain network | Inter-hemispheric similarity of pFC | F(3,21) = 3.87, p = 0.024 | 0.43 (0.081) | 0.48 (0.062) | 0.48 (0.059) | 0.47 (0.060) | op − 1d < op + 1d: p = 0.037 | N.S. | N.S. |
| op − 1d < op + 7d: p = 0.036 | |||||||||
| Average strength of pFC | F(3,21) = 3.65, p = 0.029 | 0.1565 (0.0044) | 0.1506 (0.0056) | 0.1571 (0.0055) | 0.1559 (0.0030) | op − 1d > op + 1d: p = 0.065 | N.S. | N.S. | |
| op + 1d < op + 3m: p = 0.037 | |||||||||
| Path-length of left planum polare in FC | F(3,21) = 9.30, p = 0.000 | 4.05 (0.92) | 5.10 (1.19) | 4.05 (0.57) | 3.93 (0.90) | op − 1d < op + 1d: p = 0.002 | N.S. | N.S. | |
| op + 1d > op + 7d: p = 0.002 | |||||||||
| op + 1d > op + 3m: p = 0.001 | |||||||||
| Path-length of right lateral inferior occipital cortex in pFC | F(3,21) = 18.27, p = 0.000 | 19.01 (1.65) | 21.80 (1.26) | 18.30 (1.36) | 18.78 (1.77) | op − 1d < op + 1d: p = 0.000 | N.S. | N.S. | |
| op + 1d > op + 7d: p = 0.000 | |||||||||
| Op + 1d > Op + 3m: p = 0.000 | |||||||||
GPe, external globus pallidum; SN, substantia nigra; N.S., not significant; FC, functional connectivity-based on Pearson correlation; pFC, partial-correlation functional connectivity. Values in the op − 1d, op + 1d, op + 7d, and op + 3m indicate mean and SDs.