Table 2. Overview of various measures of epigenetic age acceleration.
| Measure of age acceleration | Short name of measure | Epigenetic age estimate | Uses blood counts | Correlation with blood counts | Conserved in breast tissue |
|---|---|---|---|---|---|
| (Universal) epigenetic age acceleration | AgeAccelHorvath (AgeAccel) | Horvath: 353 CpGs | no | weak | yes |
| Intrinsic epigenetic age acceleration (Horvath) | IEAA.Horvath (IEAA) | Horvath: 353 CpGs | yes | very weak | yes |
| Age acceleration based on Hannum | AgeAccelHannum | Hannum: 71 CpGs | no | moderate | no |
| Intrinsic epigenetic age acceleration (Hannum) | IEAA.Hannum | Hannum: 71 CpGs | yes | very weak | no |
| Extrinsic epigenetic age acceleration | EEAA | Enhanced Hannum | yes | strong | no |
Description of the differences between epigenetic age and age acceleration measures. Column “Correlation with blood counts” relates to Supplementary Table 4. Column “Conserved in breast tissue” relates to Figure 1