Table 3. Canonical pathways identified in aged C57BL/6 and Atp8b1 mutant lungs.

Name	Molecules	-log(p-value)
Top Canonical Pathways in C57BL/6 Mice
Vitamin-C Transport	GSTO2,SLC23A1	2.48E00
Intrinsic Prothrombin Activation Pathway	COL3A1,COL1A1	1.91E00
Hematopoiesis from Pluripotent Stem Cells	IGHM,IGHA1	1.91E00
L-carnitine Biosynthesis	BBOX1	1.73E00
Ascorbate Recycling (Cytosolic)	GSTO2	1.73E00
Top Canonical Pathways in Atp8b1 Mice
Name	Molecules	-log(p-value)
OX40 Signaling Pathway	HLA-A,CD3G,HLA-DQA1,HLA-DQB1,CD3D,HLA-DMB,HLA-DOB,B2M,NFKBIE	6.25E00
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	SLAMF1,TNFRSF17,CD28,CXCL13,HLA-DQA1,TNFRSF13B,HLA-DQB1,CD79B,	6.06E00
	HLA-DMB,HLA-DOB,SPP1
Communication between Innate and Adaptive Immune Cells	TNFRSF17,CD28,HLA-A,CD8A,CCL5,CXCL10,TNFRSF13B,Ccl9,B2M,IGHA1	6.06E00
Antigen Presentation Pathway	HLA-A,CD74,HLA-DQA1,HLA-DMB,HLA-DOB,B2M,PSMB8
Agranulocyte Adhesion and Diapedesis	CCXL9,CCL8,CCL5,CXCL10,MMP12,CCL20, MMP13,Glycam1,Ppbp,CXCL6,CCL19, CXCL13, CCL9, CXCL3,MYL3	5.98E00