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. 2016 Oct;2(5):574–582. doi: 10.1016/j.jacep.2016.03.007

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Reduced Heterogeneity of Fibrosis at IBZ of Rotigaptide-Treated Hearts

(A) Representative biventricular slices from the mid-ventricles of MI hearts stained with Masson’s trichrome. (B) No differences are seen in infarct size between groups. (C) Sample images of the IBZ from control and rotigaptide hearts show complex interaction between fibrosis (blue) and surviving myocardium (reddish-pink). (D) Mean IBZ ICRs were not different between groups. (E) Rotigaptide reduced the dispersion of ICR (SD of ICR values within each heart) compared to control MI hearts (*p < 0.05). (F) Cx43 lateralization scoring system. (Left) Normal Cx43 localization at the intercalated discs. (Right) Significant lateralization of Cx43 as shown by arrows. (G) Cx43 lateralization scores were not different between groups. CON n = 10; ROT n = 9. ICR = interface complexity ratio.