Figure 5.

The effects of intravenous injection of oncolytic virus M1 on the cytokines and the lymphocyte subsets in the peripheral blood of cynomolgus macaques. Protein levels of cytokines, including TNF-α (A), IL-2 (B), IL-6 (C), IL-10 (D), and IL-12 (E), at indicated time points were detected using ELISA. Data from test animals shown in black lines versus data from control animals shown in gray lines are both in ng/dl with the exception of TNF-α (in fmol/ml). Comparative studies on lymphocyte classification (F) in the peripheral blood between the test group and the control group were performed immediately after whole blood collection using immunocytometric methods. Data are shown as mean ± SD, bars indicate standard deviations, and significant results are indicated if the p value is less than 0.05.