Table 1.

Data collection schedule for the safety study of alphavirus M1

	Study day
Procedure	0	1	2	3	4	5	6	7	13	21	28	32	39	46	53	60	67	74	81	88	95	105
Body weight	×					×			×	×		×	×	×	×	×	×	×	×	×	×	×
Temperature	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×
Clinical observation	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×
Hematology	×		×		×	×	×	×	×	×	×		×	×	×	×	×	×	×	×	×
Blood biochemistry	×					×			×	×	×		×	×	×	×	×	×	×	×	×
Cytokine	×	×	×	×				×	×	×	×	×	×	×	×	×	×	×	×	×	×
Urine	×								×	×	×		×	×	×	×	×	×	×	×	×
M1 titration (blood)		×	×	×	×
qRT-PCR (blood)		×	×	×	×
Neutralization assay	×			×						×											×

M1, oncolyticvirus M1; qRT-PCR, quantitative real-time polymerase chain reaction.