Table 4.

Comparison of main outcome measures between two groups of macaques at the end of the safety study of oncolytic virus M1

Diagnosis	Control, n = 5	Test, n = 5	p ≥ 0.05a
Body weight	5.26 ± 1.39	5.81 ± 0.8	Yes
Anorexia	0 (0)	0 (0)
Body temperature	38.42 ± 0.48	38.22 ± 0.52	Yes
Clinical symptomsb	0 (0)	0 (0)
WBC, cells/nl	11.12 ± 4.31	9.54 ± 4.01	Yes
PLT, cells/nl	432.8 ± 51.09	350 ± 109.60	Yes
NG, %	57.46 ± 11.34	40.22 ± 12.31	Yes
LY, %	34.72 ± 9.62	51.16 ± 12.14	0.0450
MONO, %	4.86 ± 2.32	5.2 ± 3.17	Yes
HCT, %	40.82 ± 3.35	42.64 ± 2.69	Yes
CK-MB, U/liter	255.6 ± 117.10	194.2 ± 39.24	Yes
AST, U/liter	28 ± 5.24	28.2 ± 4.55	Yes
ALT, U/liter	32.4 ± 16.77	26.4 ± 3.78	Yes
ALB, g/liter	44.66 ± 2.79	46.22 ± 1.81	Yes
GLB, g/liter	32 ± 3.50	30.26 ± 4.11	Yes
ALP, U/liter	175 ± 76	181.8 ± 70.48	Yes
CHOL, mM	3.09 ± 0.94	3.60 ± 0.78	Yes
TBIL, μM	1.3 ± 0.56	1.14 ± 0.62	Yes
BUN, mM	6.44 ± 1.18	6.14 ± 1.10	Yes
Cr, μM	64.8 ± 13.37	67 ± 12.86	Yes
Viremia	0 (0)	0 (0)
IL-2, ng/dl	2.75 ± 0.33	3.33 ± 0.53	Yes
IL-6, ng/dl	93.57 ± 6.85	95.75 ± 18.17	Yes
IL-10, ng/dl	28.43 ± 7.33	22.85 ± 4.36	Yes
IL-12, ng/dl	211.33 ± 39.32	168.01 ± 91.57	Yes
TNF-alpha, fmol/ml	21.93 ± 2.05	20.1 ± 42.19	Yes
Abnormal MRI	0 (0)	0 (0)

^ap < 0.05, statistically significant differences between the control group and the test group.

^bClinical symptoms including emesis, diarrhea, circling, aggression, vocalization, hunched posture, paddling, and recumbent.

ALB, albumin; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CHOL, cholesterol; CK-MB, creatine kinase-MB; Cr, creatinine; GLB, globulin; HCT, hematocrit; LY, lymphocyte; MONO, monocyte; NG, neutrophilic granulocyte; PLT, platelet; TBIL, total bilirubin; WBC, white blood cell.