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. 2016 Sep 1;27(3):111–122. doi: 10.1089/humc.2016.061

Figure 3.

Figure 3.

Toxicology and biodistribution study after intravenous administration of VSV-mIFNβ-NIS in C57BL/6 mice. (a) Body weight of male and female mice that received saline or 108, 3 × 108, or 109 TCID50 of VSV. (b) Platelet, (c) lymphocyte, (d) aPTT, (e) PTT, (f) AST, and (g) ALT levels in mice on day 2 postadministration of test articles. Biodistribution of VSV-N RNA was analyzed by qRT-PCR of the (h) spleen, (i) liver, (j) brain, and (k) blood of mice given saline or 109 TCID50 of VSV on day 2, 7, 21, or 58 postadministration of test articles. Limit of detection: >103 copy/μg RNA. The horizontal bars represent the mean + SEM value of the group (b–g) or mean value (h–k). Dotted lines represent the limit of detection: 103 copies/μg RNA for qRT-PCR.