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Schematic model summarizing Orai1, TRPC1, and CaV1.2 co-activation upon 5-HT stimulation. We propose that 5-HT binding to its receptors promotes InsP3-induced Ca2+ release, depletion of Ca2+ stores, activation of Ca2+ entry through Orai1, and TRPC1-dependent SOCC. The consequent SOCE will trigger secondary activation of LTCC, allowing a significant increase in intracellular free Ca2+ concentration and further aorta contraction.
