FIGURE 5.

Structure of brartemicin analog bound to the extended CRD of mincle. A, chemical structure of brartemicin analog. B, Fo-Fc omit map showing the brartemicin analog with electron density contoured at 3 σ. C, overlay of brartemicin and brartemicin analog structures. In this panel, carbon atoms in brartemicin are colored light brown, and carbon atoms of the analog are shown in yellow, with protein carbon atoms of the CRD shown in gray for the brartemicin complex and cyan for the analog complex. D, surface representation of brartemicin analog in the binding site of mincle. Atoms are represented as in Fig. 2.