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Solution structures of [S39_PQ]IGF-II (orange) and [N29,S39_PQ]IGF-II (purple) compared with non-modified IGF-II (gray). A and B show representative structures of the Domain 11-bound IGF-II analogs, and C and D show sets of 20 converged structures bound to D11 (white). The insertion of Pro-Gln in the C-domain after position 39 led to a significant structural rearrangement of the semiflexible loop.
