Table 1.
Inflammasomes in vascular diseases and risk factors for brain disease.
| Comorbidity | Inflammasome activated | Trigger |
|---|---|---|
| Type 2 diabetes | NLRP3128,129 | Hyperglyceamia,130 ATP, HMGB1, FFAs, IAPP, MSU,128 SFAs131 |
| Atherosclerosis | NLRP3132,133 | Cholesterol crystals133 |
| Hyperlipidaemia and obesity | NLRP3 | Cholesterol crystals101 |
| NLRP1134a | Ceramide135 | |
| Hypertension | NLRP3 | Hypoxia, high salt levels136–138 |
| Gout and arthritis | NLRP3, NLRC4139 | MSU, CPPD crystals140 |
Inflammasomes involved in different conditions and triggers identified were listed. See explanation in the text.
a
Inflammasome activation is associated with a protective phenotype.