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. 2016 Oct 18;10:3387–3397. doi: 10.2147/DDDT.S113171

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© 2016 Al Asmari and Khan. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of Leiurus quinquestriatus venom extract on Bcl2 expression in chemically induced skin tumors.

Notes: Representative photomicrographs (magnification ×40; scale bar: 50 μm). (A) Group I: only vehicle (0.2 mL acetone); (B) Group II: DMBA + croton oil; (C) Group III: DMBA + croton oil + L. quinquestriatus venom (17.5 μg per mouse); (D) Group IV: DMBA + croton oil + L. quinquestriatus venom (35 μg per mouse); and (E) Group V: DMBA + croton oil + L. quinquestriatus venom (52.5 μg per mouse). Group II animals showed more immunopositive staining of Bcl2 (arrows) compared with Group I animals. L. quinquestriatus venom-treated animal groups exhibit reduced Bcl2 expression (arrows) compared to Group II animals.

Abbreviations: Bcl2, B-cell lymphoma-2; DMBA, 7,12-dimethylbenz[a]anthracene.