TABLE 2.

List of Inhibitors

Signaling pathways and factors examined for involvement in the alternative splicing of Bcl-x pre-mRNA modulated by MDA-7/IL-24 as analyzed by small molecule inhibitors are shown. The table depicts the inhibitors and their respective concentrations utilized in this study. Signaling pathways were examined for effects on the ratio of Bcl-x(L)/(s) mRNA utilizing small-molecule inhibitors at doses well characterized in the scientific literature and previously utilized in studies on A549 cells (43–47). mTOR, mammalian target of rapamycin. N/C, no change; iPLA2, intracellular phospholipase A2.

Inhibitor	Method of action	Concentration	Outcome
Salubrinal	ER stress inhibitor	15 μm	N/C
Bromoenol lactone (BEL)	iPLA2 inhibitor	20 μm	N/C
PKC Y translocation peptide	PKCϵ inhibitor	100 μm	N/C
Rapamycin	mTOR inhibitor	10 μm	N/C
Gö 6983	Pan-PKC inhibitor	100 nm	Inhibition
Rottlerin	PKCδ inhibitor	50 μm	Inhibition
Src inhibitor-1	Src inhibitor	50 nm	Inhibition
PKCδ siRNA	PKCδ inhibitor	100 nm	Inhibition
SRC siRNA	SRC inhibitor	100 nm	Inhibition