FIGURE 1.

GC-induced hepatic steatosis is dependent on ATF3 deficiency. WT and ATF3^−/− mice (n = 6) were injected with Dex (1 mg/kg weight/day) or DMSO (Veh) for 5 days. A, ratio of liver to body weight and lipid contents in the serum and liver were measured. TG, triglyceride; Chol, cholesterol; FFA, free fatty acids. Data represent the mean ± S.E. of all mice analyzed. *, p < 0.05; **, p < 0.01, unpaired t tests. B, representative results of Oil-Red O staining and hematoxylin and eosin (HE) staining of liver section. Original magnification, ×200.