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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Nat Chem Biol. 2015 Dec;11(12):891–894. doi: 10.1038/nchembio.1962

Figure 2.

Figure 2

Transcription complexes are dynamic in composition and conformation. (a) The BAF chromatin remodeling complexes contain the same enzymatic core (BRG1) but have exchangeable subunits such as BAF45a and BAF45b that define tissue specificity. See ref. 10 for a more complete discussion of the composition and function of these complexes. (b) The GACKIX (Gal11, Arc105, CBP/p300, kinase-inducible domain interacting) motif of CBP/p300 uses two binding sites to interact with more than 10 distinct transcriptional activators. (c) Each ternary complex has a signature conformation with the two binding sites in allosteric communication. The structure and function of the GACKIX motif were recently reviewed in ref. 14.