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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Sep 3;26(20):5000–5006. doi: 10.1016/j.bmcl.2016.09.001

Figure 1.

Figure 1

Plot of net exchange efflux rate (fmol/min) of [3H]-gabapentin from pre-loaded HEK-hLAT1 cells vs. Leu (1e) concentration (μM). Net efflux rate was calculated by subtracting the exchange rate without Leu (1e) (marked by a dotted line) from the efflux rate at Leu (1e) concentrations of 4, 10, 32, 80 and 200 μM. Solid line represents a non-linear regression fit of the data to Michaelis-Menten kinetics.