Table 5. Between group effects (PD vs. HC) for the HPS condition.
| Cytoarchitectonic region | Side | K | T | Z | x | y | z |
|---|---|---|---|---|---|---|---|
| Between group effects HPSPD > HPSHC | |||||||
| Precuneus | R | 97 | 4.86 | 4.01 | 12 | -52 | 46 |
| Precuneus | R | 3.94 | 3.43 | 9 | -70 | 37 | |
| Precuneus, 5m (SPL) | R | 92 | 4.67 | 3.90 | 3 | -49 | 61 |
| Precuneus | L | 3.78 | 3.32 | -6 | -55 | 43 | |
| 5Ci (SPL) | L | 3.76 | 3.30 | -15 | -46 | 46 | |
| Posterior cingulate cortex | R | 91 | 5.72 | 4.50 | 6 | -31 | 22 |
| Precuneus | R | 4.03 | 3.49 | 6 | -46 | 13 | |
| Medial frontal gyrus | R | 49 | 4.65 | 3.89 | 27 | 41 | 28 |
| Thalamus, parietal | L | 45 | 4.40 | 3.73 | -15 | -25 | 4 |
| Thalamus, temporal | L | 4.19 | 3.59 | -9 | -25 | 13 | |
| Thalamus, parietal | R | 38 | 4.79 | 3.97 | 21 | -28 | 7 |
Maxima of activation clusters for the HPS condition in patients with early-staged Parkinson’s disease (PD, OFF state) vs. healthy control subjects (HC). Statistical threshold: p < 0.05, FWE cluster corrected; italic: trend activation at p < 0.001, uncorrected (extent threshold 38 vx). HC: control subjects, HPS: high pain laser stimulus with higher target energy (E = 600 mJ), K: cluster size, L: left, LPS: low pain laser stimulus with lower target energy (E = 440 mJ), R: right, SPL: superior parietal lobule, T: T values, X/Y/Z: coordinates in MNI space, Z: Z scores.