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. 2016 Oct 24;11(10):e0165256. doi: 10.1371/journal.pone.0165256

Fig 2. Fear recall suppresses mPFC population level single-unit activity.

Fig 2

(A) Day 2 design. (B) Upon tone presentation on Day 2, signaled (red) and unsignaled rats (blue) displayed opposing freezing patterns. (C, D) Average normalized firing rate data from PL and IL are binned in 5 sec increments for the duration of the session. Gray dashed lines indicate tone onset (tone response is the bar immediately to the right of dashed line) for the 5 tones. Signaled rats exhibited robust tone-evoked responses that are superimposed on the overall suppression of neural activity in both PL and IL, as compared to the general increase in firing in unsignaled PL and IL. (E) Heat maps plotting tone-evoked responses for neurons from signaled and unsignaled rats. (F) Normalized tone-evoked histogram averages plotted in 100 msec bins for PL and IL. Previously signaled rats showed robust tone-evoked responses in both PL and IL around tone onset (first 200 msec) compared to unsignaled rats. No difference was observed between brain regions when comparing within a shock group. All values are means ± SEM.