Skip to main content
. 2016 Oct 24;11(10):e0163324. doi: 10.1371/journal.pone.0163324

Fig 4. Inhibitory effect of intrathecal ZIP injection on EMG response in IBS-like rats.

Fig 4

A: EMG amplitude at 20–80 mmHg CRD pressure after saline in IBS-like rats. B: EMG amplitude at 20–80 mmHg CRD pressure after 1 μg ZIP in IBS-like rats. C: EMG amplitude at 20–80 mmHg CRD pressure after 5 μg ZIP in IBS-like rats. D: EMG amplitude at 20–80 mmHg CRD pressure after 10 μg ZIP in IBS-like rats. ZIP dose-dependently inhibited the chronic visceral hypersensitivity in IBS-like rats; n = 10, respectively. *p < 0.05 vs. pre-drug. EMG: electromyography; CRD: colorectal distention; IBS: irritable bowel syndrome; ZIP: PKMζ inhibitor.