| Age, mean(SD) |
59.5 |
(12.6) |
65.0 |
(14.2) |
<0.001 |
58.9 |
(12.5) |
65.5 |
(11.4) |
<0.001 |
64.3 |
(11.8) |
<0.001 |
| Educational level |
|
|
|
|
<0.001 |
|
|
|
|
<0.001 |
|
|
<0.001 |
|
Less than primary school |
197 |
(15%) |
52 |
(41%) |
|
259 |
(16%) |
108 |
(30%) |
|
65 |
(33%) |
|
|
Primary school completed |
422 |
(33%) |
47 |
(37%) |
|
490 |
(31%) |
140 |
(38%) |
|
74 |
(38%) |
|
|
Secondary school |
392 |
(30%) |
24 |
(19%) |
|
495 |
(31%) |
73 |
(20%) |
|
35 |
(18%) |
|
|
University graduate |
282 |
(22%) |
5 |
(4%) |
|
361 |
(22%) |
43 |
(12%) |
|
22 |
(11%) |
|
| BMI |
|
|
|
|
0.003 |
|
|
|
|
<0.001 |
|
|
0.045 |
|
<20 Kg/m2
|
91 |
(7%) |
5 |
(4%) |
|
111 |
(7%) |
15 |
(4%) |
|
13 |
(7%) |
|
|
20–24 Kg/m2
|
542 |
(42%) |
36 |
(28%) |
|
681 |
(42%) |
116 |
(32%) |
|
64 |
(33%) |
|
|
25–29 Kg/m2
|
409 |
(32%) |
50 |
(39%) |
|
506 |
(32%) |
139 |
(38%) |
|
78 |
(40%) |
|
|
>29 Kg/m2
|
251 |
(19%) |
37 |
(29%) |
|
307 |
(19%) |
94 |
(26%) |
|
41 |
(21%) |
|
| Smoking |
|
|
|
|
0.001 |
|
|
|
|
<0.001 |
|
|
0.004 |
|
Never smoker |
778 |
(60%) |
97 |
(76%) |
|
934 |
(58%) |
257 |
(71%) |
|
135 |
(69%) |
|
|
Former smoker > 1.5 years |
257 |
(20%) |
10 |
(8%) |
|
332 |
(21%) |
56 |
(15%) |
|
38 |
(19%) |
|
|
Smoker or former smoker <1.5 years |
258 |
(20%) |
21 |
(16%) |
|
339 |
(21%) |
51 |
(14%) |
|
23 |
(12%) |
|
| Family history colorectal/gastric cancer |
|
|
|
|
<0.001 |
|
|
|
|
<0.001 |
|
|
0.005 |
|
None |
1160 |
(90%) |
90 |
(70%) |
|
1397 |
(87%) |
283 |
(78%) |
|
160 |
(82%) |
|
|
Second degree only |
77 |
(6%) |
9 |
(7%) |
|
67 |
(4%) |
15 |
(4%) |
|
7 |
(4%) |
|
|
1 first degree |
53 |
(4%) |
20 |
(16%) |
|
129 |
(8%) |
55 |
(15%) |
|
23 |
(12%) |
|
|
>1 first degree |
3 |
(0%) |
9 |
(7%) |
|
12 |
(1%) |
11 |
(3%) |
|
6 |
(3%) |
|
| Age at menarche, mean(SD) |
12.8 |
(1.7) |
13.2 |
(2.0) |
0.018 |
12.8 |
(1.6) |
13.0 |
(1.7) |
0.024 |
13.2 |
(1.6) |
0.006 |
| Number of children |
|
|
|
|
0.006 |
|
|
|
|
0.001 |
|
|
0.047 |
|
None |
235 |
(18%) |
22 |
(17%) |
|
278 |
(17%) |
43 |
(12%) |
|
27 |
(14%) |
|
|
1–2 |
716 |
(55%) |
55 |
(43%) |
|
902 |
(56%) |
190 |
(52%) |
|
99 |
(51%) |
|
|
3–4 |
279 |
(22%) |
39 |
(30%) |
|
350 |
(22%) |
103 |
(28%) |
|
58 |
(30%) |
|
|
>4 |
61 |
(5%) |
12 |
(9%) |
|
72 |
(4%) |
28 |
(8%) |
|
12 |
(6%) |
|
| Age at first birth, mean(SD) |
26.7 |
(4.8) |
24.8 |
(4.7) |
<0.001 |
26.8 |
(4.8) |
26.2 |
(4.5) |
0.040 |
26 |
(5.2) |
0.051 |
| Lactation first child (months), mean(SD) |
4.5 |
(5.7) |
5.5 |
(5.8) |
0.113 |
4.4 |
(5.6) |
5.4 |
(6.1) |
0.008 |
5.6 |
(6.1) |
0.020 |
| History of miscarriages |
|
|
|
|
0.768 |
|
|
|
|
0.013 |
|
|
0.597 |
|
None |
985 |
(76%) |
99 |
(77%) |
|
1231 |
(77%) |
301 |
(83%) |
|
147 |
(75%) |
|
|
One or more |
308 |
(24%) |
29 |
(23%) |
|
374 |
(23%) |
63 |
(17%) |
|
49 |
(25%) |
|
| Menopausal status |
|
|
|
|
0.001 |
|
|
|
|
<0.001 |
|
|
<0.001 |
|
Premenopausal |
340 |
(26%) |
17 |
(13%) |
|
456 |
(28%) |
39 |
(11%) |
|
29 |
(15%) |
|
|
Posmenopausal |
953 |
(74%) |
111 |
(87%) |
|
1149 |
(72%) |
325 |
(89%) |
|
167 |
(85%) |
|
| Hormonal contraception use |
|
|
|
|
<0.001 |
|
|
|
|
<0.001 |
|
|
<0.001 |
|
Never |
668 |
(52%) |
101 |
(79%) |
|
809 |
(50%) |
254 |
(70%) |
|
135 |
(69%) |
|
|
Ever |
625 |
(48%) |
27 |
(21%) |
|
796 |
(50%) |
110 |
(30%) |
|
61 |
(31%) |
|
| Postmenopausal women |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Hormone therapy use |
|
|
|
|
0.121 |
|
|
|
|
<0.001 |
|
|
0.016 |
|
Never |
858 |
(90%) |
105 |
(95%) |
|
1025 |
(89%) |
311 |
(96%) |
|
159 |
(95%) |
|
|
Ever |
95 |
(10%) |
6 |
(5%) |
|
124 |
(11%) |
14 |
(4%) |
|
8 |
(5%) |
|
| Age at menopause, mean(SD) |
48.4 |
(5.3) |
47.9 |
(5.6) |
0.397 |
48.6 |
(5.3) |
48.7 |
(5.2) |
0.667 |
48.7 |
(5.0) |
0.663 |
| Fertility time (years), mean(SD) |
35.5 |
(5.4) |
34.7 |
(5.7) |
0.183 |
35.7 |
(5.4) |
35.7 |
(5.2) |
0.949 |
35.5 |
(4.9) |
0.638 |
